A case of anaphylaxis to Pollinex® Quattro MPL-4.
نویسندگان
چکیده
We described the first case reported in literature of anaphylactic shock after administration of pollen extract vaccine chemically modified (allergoid) adsorbed onto L-Tyrosine depot adjuvanted with monophosphoryl lipid A (Pollinex® Quattro MPL-4).
منابع مشابه
Standardisation of glutaraldehyde-modified tyrosine-adsorbed tree pollen vaccines containing the Th1-inducing adjuvant, monophosphoryl lipid A (MPL).
BACKGROUND a new range of allergy vaccines has been developed by the introduction of a relatively new Th1-inducing adjuvant known as 3-deacylated monophosphoryl lipid A (MPL). MPL adjuvant is of natural origin, derived from the lipopolysaccharide of Salmonella minnesota R595. This adjuvant is incorporated in a glutaraldehyde-modified pollen extract adsorbed to L-tyrosine (Pollinex Quattro). A m...
متن کاملAllergoid-specific T-cell reaction as a measure of the immunological response to specific immunotherapy (SIT) with a Th1-adjuvanted allergy vaccine.
BACKGROUND Specific immunotherapy (SIT) is believed to modulate CD4+ T-helper cells. In order to improve safety, SIT vaccines are often formulated with allergoids (chemically modified allergens). Interaction between T-cells and allergoids is necessary to influence cellular cytokine expression. There have been few reports on identification the early cellular effects of SIT. METHOD Patients all...
متن کاملMonophosphoryl Lipid a as an adjuvant for immune therapy? A detailed in vitro comparison to LPS
Monophosphoryl lipid A (MPL) is a non-toxic TLR4 ligand, derived from Salmonella minnesota R595 (Re) lipopolysaccharide (LPS) by chemical modification. It is clinically used as an adjuvant for cancer treatment (Fendrix, Ceravix) and allergen specific immunotherapy (Pollinex Quattro, ORALVAC). Nevertheless, reports on the mechanism of adjuvant activity are limited. The aim of this study was to c...
متن کاملAnti-inflammatory effects of pre-seasonal Th1-adjuvant vaccine to Parietaria judaica in asthmatics
BACKGROUND The ultra-short course pre-seasonal allergy vaccine, containing appropriate allergoids with the adjuvant monophosphoryl lipid A (MPL), may be effective in treating allergic symptoms. OBJECTIVE To explore the timing of the immunological responses to the pre-seasonal allergy vaccine. METHODS Four subcutaneous injections of the active product (Pollinex Quattro) were administered to ...
متن کاملCost-Effectiveness Analysis of Allergen Immunotherapy in Patients With Grass Pollen-Induced Allergic Rhinitis in Spain.
• Allergic rhinoconjunctivitis (AR) is defined as inflammation of the nasal membranes, and is characterized by a combination of the following symptoms: sneezing, nasal congestion, nasal itching, rhinorrhoea, watery and ocular itching. • Surveys of individuals with AR conducted in Europe indicate that poorly controlled AR has a substantial detrimental impact on quality of life (QoL), as well as ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- European annals of allergy and clinical immunology
دوره 46 1 شماره
صفحات -
تاریخ انتشار 2014